Bills picks, you need to see the NFL predictions and betting advice from the SportsLine Projection Model. Broncos odds while the over/under for total points scored is 47.5. Buffalo is a 7.5-point favorite in the latest Bills vs. Denver upset Kansas City 24-9 in an AFC West showdown before their week off. The Bills played on Sunday Night Football in Week 9, losing 24-18 to the Bengals.
Meanwhile, the Broncos (3-5) have won consecutive games and come in off their bye week. The Bills (5-4) have made the postseason four straight years, but they come into the Week 10 NFL matchup at Highmark Stadium with three losses in their past five games. The Buffalo Bills will host the Denver Broncos on Monday Night Football to close out NFL Week 10.